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Ali, Javed
- Development and Validation of UV Spectrophotometric Method for the Quantitative Estimation of Eugenol
Authors
1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062,, IN
2 Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062
3 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 2 (2013), Pagination: 58-61Abstract
Eugenol is an allyl chain-substituted guaiacol and finds variety of applications. Thus development of a validated UV spectrophotometric method will always be advantageous as the method is simple and rapid. The method was validated according to International Conference on Harmonisation (ICH) guidelines Q2(R1) with respect to linearity and range, precision, accuracy, detection limit (DL) and quantitation limit (QL). The detection limit (DL) and quantitation limit (QL) were determined as per the ICH guidelines and were found to be 0.82 and 2.48 μg mL-1 respectively. The method is expected to be useful in a variety of industries where eugenol finds its application.Keywords
ICH, Linearity, Range, Precision, Accuracy, Detection Limit, Quantitation LimitReferences
- Pramod K, Ansari SH and Ali J. Eugenol: A natural compound with versatile pharmacological actions. Nat Prod Commun. 5 (12); 2010: 1999-2006.
- Kriegel C, Kit KM, McClements DJ, Weiss J. Nanofibers as carrier systems for antimicrobial microemulsions. II. Release characteristics and antimicrobial activity. J Appl Polym Sci. 118; 2010: 2859–2868.
- Pokharkar VB, Shekhawat PB, Dhapte VV, Mandpe LP. Development and optimization of eugenol loaded nanostructured lipid carriers for periodontal delivery. Int J Pharm Pharm Sci. 3; 2011: 138-143.
- Gomes C, Moreira RG, Castell-Perez E. Poly (DL-lactide-coglycolide) (PLGA) nanoparticles with entrapped transcinnamaldehyde and eugenol for antimicrobial delivery applications. J Food Sci. 76 (2); 2011: N16-N24.
- Shu-Ya J. 2010. Encapsulation of active substance in nanocapsules by emulsion-diffusion method [Accessed 12 February 2011]. Available from: URL: http://140.121.155.217/ seminar/19932033-1.pdf.
- Shah A, Garg A, Sairam K, Singh S. 2010. Pharmacological evaluation of eugenol loaded solid lipid nanoparticles in irritable bowel syndrome [Accessed 10 March 2011]. Available from: URL: www.scientificipca.org/paper/2009/09/25/20090925 1910570A.doc.
- Chen F, Shi Z, Neoh KG, Kang ET. Antioxidant and antibacterial activities of eugenol and carvacrol-grafted chitosan nanoparticles. Biotechnol Bioeng. 104 (1); 2009: 30-39.
- Jadhav BK, Khandelwal KR, Ketkar AR, Pisal SS. Formulation and evaluation of mucoadhesive nanocapsules containing eugenol for the treatment of periodontal diseases. Drug Dev. Ind. Pharm. 30; 2004: 195-203.
- Chaieb K, Hajlaoui H, Zmantar T, Kahla-Nakbi AB, Rouabhia M, Mahdouani K, Bakhrouf A. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. Phytother. Res. 21; 2007: 501-506.
- ICH-Guidelines Q2(R1). Validation of Analytical Procedures: Text and Methodology. Geneva, Switzerland: 2005.
- UV Spectrophotometric Method for the Quantification of Eugenol during in Vitro Release Studies
Authors
1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062, IN
2 Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 3, No 3 (2013), Pagination: 86-89Abstract
Polysorbate 80 (Tween 80®) is a commonly used media for solubilizing eugenol and thus could be employed as a solubilizer in the in vitro release studies of eugenol from its dosage forms. Till date no studies have been reported a validated UV spectrophotometric assay method for the estimation of eugenol in dissolution media containing Tween 80 as solubilizer. Towards this objective of quantification of eugenol efforts have been made towards the development and validation analytical method by UV spectrophotometry. The method was validated according to International Conference on Harmonisation (ICH) guidelines Q2(R1) with respect to linearity and range, precision, accuracy, detection limit (DL) and quantitation limit (QL). The detection limit and quantitation limit were determined as per the ICH guidelines and were found to be 0.62 and 1.88 μg mL-1 respectively. Thus it was confirmed that the developed method could be employed for the quantification of eugenol from 0.5% w/v aqueous Tween 80 solutions used as aqueous phase for in vitro release studies of eugenol loaded drug delivery systems.Keywords
ICH,Tween 80, Dissolution, Drug Release, ValidationReferences
- Pramod K, Ansari SH, Ali J. Eugenol: A natural compound with versatile pharmacological actions. Nat Prod Commun. 2010; 5(12): 1999-2006.
- Gomes C, Moreira RG, Castell-Perez E. Poly (DL-lactide-coglycolide) (PLGA) nanoparticles with entrapped transcinnamaldehyde and eugenol for antimicrobial delivery applications. J Food Sci. 2011; 76(2): N16-N24.
- Kriegel C, Kit KM, McClements DJ, Weiss J. Nanofibers as carrier systems for antimicrobial microemulsions. II. Release characteristics and antimicrobial activity. J Appl Polym Sci. 2010; 118: 2859–68.
- Pokharkar VB, Shekhawat PB, Dhapte VV, Mandpe LP. Development and optimization of eugenol loaded nanostructured lipid carriers for periodontal delivery. Int J Pharm Pharm Sci. 2011; 3: 138-43.
- Shu-Ya J. 2010. Encapsulation of active substance in nanocapsules by emulsion-diffusion method [Accessed 12 February 2011]. Available from: http://140.121.155.217/ seminar/19932033-1.pdf.
- Shah A, Garg A, Sairam K, Singh S. 2010. Pharmacological evaluation of eugenol loaded solid lipid nanoparticles in irritable bowel syndrome [Accessed 10 March 2011]. Available form: www.scientificipca.org/paper/2009/09/25/200909251910570A.do c.
- Chen F, Shi Z, Neoh KG, Kang ET. Antioxidant and antibacterial activities of eugenol and carvacrol-grafted chitosan nanoparticles. Biotechnol Bioeng. 2009;104(1): 30-9.
- Jadhav BK, Khandelwal KR, Ketkar AR, Pisal SS. Formulation and evaluation of mucoadhesive nanocapsules containing eugenol for the treatment of periodontal diseases. Drug Dev. Ind. Pharm. 2004; 30: 195-203.
- Wang JX, Zhang ZB, Le Y, Zhao H, Chen JF. A novel strategy to produce highly stable and transparent aqueous 'nanosolutions' of water-insoluble drug molecules. Nanotechnology 2011; 22(30): 1-7.
- Iannitelli A, Grande R, Di Stefano A, Di Giulio M, Sozio P, Bessa LJ, Laserra S, Paolini C, Protasi F, Cellini L. Potential antibacterial activity of carvacrol-loaded Poly(DL-lactide-coglycolide) (PLGA) nanoparticles against microbial biofilm. Int. J. Mol. Sci. 2011; 12(8): 5039-51.
- Kurian R, Arulmozhi DK, Veeranjaneyulu A, Bodhankar SL. Effect of eugenol on animal models of nociception. Indian J. Pharmacol. 2006; 38: 341-5.
- ICH-Guidelines Q2(R1). Validation of Analytical Procedures: Text and Methodology. Geneva, Switzerland: 2005
- Assessment of Phase Diagrams by Cut and Weigh Method: A Technical Note
Authors
1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi–110062, IN
2 Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi – 110062, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 3 (2013), Pagination: 102-104Abstract
A good number of manuscripts are being published where the authors carry out qualitative assessment of the region of interest in the phase diagrams. These qualitative assessments can be sensed as a lack of sound technique for quantitative assessment. In the present technical note we have developed a simple cut and weigh method to offer a quantitative method for assessing phase diagrams. The method was validated and explained using sample analysis. The method was found to be robust, quantitative and enabled statistical comparison of the results. The method was found to be excellent even when applied for samples below a weight of 10 mg and that too on different paper sheets. The suggested technique of expressing the result as a percentage of the total area could offer a universal applicability of the method for assessment of phase diagrams. The developed and validated method would be a great tool for the researchers requiring quantitative assessment of phase diagrams.Keywords
Nanoemulsion, Microemulsion, Validation, p valueReferences
- Bali V, Ali M, Ali J: Nanocarrier for the enhanced bioavailability of a cardiovascular agent: in vitro, pharmacodynamic, pharmacokinetic and stability assessment. Int J Pharm. 403; 2011:46-56. /2. Parveen R, Baboota S, Ali J, Ahuja A, Vasudev SS, Ahmad S: Oil based nanocarrier for improved oral delivery of silymarin: In vitro and in vivo studies. Int J Pharm. 413; 2011: 245-53.
- Bali V, Ali M, Ali J: Novel nanoemulsion for minimizing variations in bioavailability of ezetimibe. J Drug Target. 18; 2010: 506-519.
- Bali V, Ali M, Ali J: Study of surfactant combinations and development of a novel nanoemulsion for minimising variations in bioavailability of ezetimibe. Colloids Surf B Biointerfaces. 76; 2010: 410-420.
- Kawtikwar PS, Kulkarni NP, Yadav S, Sakarkar DM: Formulation and evaluation of an anti-epileptic drug-loaded microemulsion for nose to brain delivery. Asian J Pharm. 3; 2009:143-147.
- Zhu W, Guo C, Yu A, Gao Y, Cao F, Zhai G: Microemulsionbased hydrogel formulation of penciclovir for topical delivery. Int J Pharm. 378; 2009:152-158.
- Shakeel F, Baboota S, Ahuja A, Ali J, Aqil M, Shafiq S: Nanoemulsions as Vehicles for Transdermal Delivery of Aceclofenac. AAPS PharmSciTech. 8; 2007: E1-E9.
- Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M: Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm. 66; 2007: 227-243.
- Shafiq-un-Nabi S, Shakeel F, Talegaonkar S, Ali J, Baboota S, Ahuja A, Khar RK, Ali M: Formulation Development and Optimization Using Nanoemulsion Technique: A Technical Note. AAPS PharmSciTech. 8(2); 2007: E1-E6.
- Validated HPLC-UV Method for Simultaneous Determination of Some Anti-Inflammatory and Analgesic Drugs
Authors
1 JK College of Pharmacy, Bilaspur, CG-495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi-110062, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 3 (2016), Pagination: 183-187Abstract
In the presented work identification and quantification of some anti-inflammatory and analgesic drugs, namely aceclofenac, diclofenac, paracetamol and para-aminophenol were carried out by validated HPLC-UV method. The chromatographic separation was achieved on HPLC C18 (100.0 × 2.1 mm, 1.7μm) column using isocratic mobile phase consisting of acetonitrile-phosphate buffer (50:50, v/v) at a flow rate of 1.0 mL/min. The UV detection was carried out at 275 nm for all the compounds. The elution of aceclofenac, diclofenac, paracetamol and para-aminophenol was occurred at 7.0, 9.2, 2.0 and 4.2 min, respectively. The calibration curves were linear over the concentration range of 1-1000 μg/mL for aceclofenac and paracetamol, and 1-100 μg/mL for diclofenac and para-aminophenol. The developed method was validated according to ICH guidelines. The method was applied in the identification and quantitative determination of these compounds during routine quality control analysis and in stability studies.Keywords
HPLC-UV, Aceclofenac, Paracetamol, Diclofenac, Para-Aminophenol, Validation.- Fixed Dose Combination (FDC) Products:Introduction, Development and Regulations
Authors
1 JK College of Pharmacy, Bilaspur, CG-495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi-110062, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 3 (2016), Pagination: 207-210Abstract
A fixed dose combination (FDC) is a formulation of two or more active ingredients combined in a single dosage form available in certain fixed doses. Combination therapy with two or more agents having complementary mechanisms of action represents a type of incremental innovation that has extended the range of therapeutic options in the treatment of almost every human disease. Combining two or more active pharmaceutical ingredients in a single-dosage form can increase a drug's efficacy and improve patient compliance. Several difficulties arise during formulation development, manufacturing and regulations of FDC products. Two or more active ingredients in the FDCs must be physically and chemically compatible along with their excipients. In this review article authors provided the brief information regarding advantages, formulation development and regulations of FDC products.- Formulation and In-Vitro Evaluation of In-Lay Matrix Tablets Containing Telmisartan and Hydrochlorothiazide
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Jamia Hamdard, New Delhi 110062, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 3 (2015), Pagination: 193-198Abstract
The aim of the presented work was formulation and in-vitro evaluation of in-lay tablets containing telmisartan as sustained release outer core and hydrochlorothiazide as immediate release inner core using HPMC and co-polymer carbopol 71G. Tablets were evaluated via various quality control tests and in-vitro drug release studies. Drug release study was carried out hydrochloric acid buffer of pH 1.2 (0.1N) using USP paddle apparatus. The validated HPLC-UV method was applied to determine the amount of drugs released at different time intervals. The mechanism of drug release through polymeric network was established. Prepared tablets showed extended sustain release of telmisartan over a period of 20 h and hydrochlorothiazide as immediate release within 30 min.Keywords
In-Lay Tablet, Telmisartan, Hydrochlorothiazide, Sustained Release, Immediate Release.- Identification of Impurities and Degradation Products in Pharmaceutical Products-Role of Hyphenated Techniques
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi, -110062, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 1 (2017), Pagination: 31-35Abstract
Impurity profiling and identification of degradation product is an essential part of pharmaceutical development program. Impurity profiling is mandatory requirement by various regulatory agencies and is directly related with the quality, safety and efficacy of a drug product. The ultimate purpose of impurity profiling and stress testing is in the establishment of the degradation products pathways and to investigate the stability-indicating power of the analytical procedures which is ultimately helpful in the prediction of shelf life of drug product. Hyphenated technique is combination a combination of two different analytical techniques with the help of proper interface. Mainly chromatographic techniques are combined with the spectroscopic techniques. This write up provides a review on brief information about role of different hyphenated analytical techniques such as HPLC-UV, HPLCMS, GC-MS and UPLC-MS/MS for identification of impurities and degradation products in pharmaceutical products.Keywords
Identification, Impurities, Degradation Products, Stress Testing, Analytical Techniques.- Validated UPLC/Q-TOF-MS Method for Simultaneous Determination of Aceclofenac, Paracetamol and Chlorzoxazone in Human Plasma and its Application to Pharmacokinetic Study
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi-110062, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 2 (2017), Pagination: 93-99Abstract
In the presented work the ultra-performance liquid chromatographic/quadrupole time-of-flight mass spectrometric (UPLC/Q-TOF-MS) method has been developed for pharmacokinetic study of some antiinflammatory and analgesic drugs in human plasma. The aceclofenac, paracetamol, and chlorzoxazone were analyzed by Acquity UPLC BEH C18 (100.0_2.1 mm, 1.7 lm) column using isocratic mobile phase consisting of acetonitrile-2mM ammonium acetate (50:50, v/v) at a flow rate of 0.20 mL/min. The Q-TOF mass spectrometer was operated in positive ionization mode and quantization was done using the MS/MS transitions m/z 354.07 to 215.07 for aceclofenac, 152.07 to 110.06 for paracetamol and 170.00 to 134.00 for chlorzoxazone. The calibration curves were linear over the concentration range of 1-1000 ng/mL for all the drugs. The developed method was validated according to ICH guidelines. The method was applied for pharmacokinetic study of tablets containing aceclofenac, paracetamol, and chlorzoxazone in human plasma.Keywords
UPLC/Q-TOF-MS, Aceclofenac, Paracetamol, Chlorzoxazone, Pharmacokinetic Study.- UHPLC:Applications in Pharmaceutical Analysis
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi, 110062, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 2 (2017), Pagination: 124-131Abstract
High Performance Liquid Chromatography (HPLC) is a major analytical technique for qualitative and quantitative drug analysis. More than 90% of drugs prescribed in official pharmacopoeias are being analyzed HPLC. But due to the higher regulatory requirements such as more number of samples, speed of analysis, and sensitivity of the method of analysis. The pharmaceutical industries adopting the more advanced chromatographic techniques. Ultra-high Performance Liquid Chromatography (UHPLC) offers an advancement of HPLC which is based on the principal of use of stationary phase consisting of particles less than 2μm. By using smaller particles, speed of analysis, peak capacity can be extended to new limits and the sample can be analyzed in a shorter period of time. The UHPLC technique is a new approach in the chromatographic separations and has been successfully employed for fast, high resolution separations with required sensitivity. This review provides the brief introduction and applications of UHPLC in the pharmaceutical analysis.Keywords
UHPLC, UPLC, Introduction, Applications, Pharmaceutical Analysis.- Application of Validated UPLC/Q-TOF-MS Method for Simultaneous Determination of Telmisartan, Hydrochlorothiazide and their Degradation Products in Tablets
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi, 110062, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 2 (2017), Pagination: 105-111Abstract
In the presented work the ultra-performance liquid chromatography/ quadrupole time-of-flight mass spectrometric (UPLC/Q-TOF-MS) method is developed for simultaneous determination of telmisartan, hydrochlorothiazide and their degradation products in tablets. For identification of drugs, the Q-TOF mass spectrometer was operated in negative ionization mode and quantification was done using the MS/MS transitions at m/z 513.18 to 469.13 for telmisartan, and 268.90 to 204.94 for hydrochlorothiazide. For quantification, the chromatographic separation was achieved on Acquity UPLCTM BEH C18 (100.0 × 2.1 mm, 1.7μm) column using isocratic mobile phase consisting of acetonitrile-2mM ammonium acetate (50:50, v/v) at a flow rate of 0.25 mL/min. The elution of telmisartan and hydrochlorothiazide was occurred at 2.25 and 1.22 min, respectively. The calibration curves were linear over the concentration range of 1-1000 ng/mL for both the drugs. The developed method was validated according to ICH guidelines.Keywords
UPLC/Q-TOF-MS, Telmisartan, Hydrochlorothiazide, Validation, Degradation Study.- Validated UPLC/Q-TOF-MS Method for Simultaneous Determination of Metformin, Glimepiride and Pioglitazone in Human Plasma and its Application to Pharmacokinetic Study
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi, 110062, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 1 (2017), Pagination: 27-32Abstract
In the presented work the ultra-performance liquid chromatographic/quadrupole time-of-flight mass spectrometric (UPLC/Q-TOF-MS) method has been developed for simultaneous determination of metformin, glimepiride and pioglitazone in human plasma. For identification of drugs, the Q-TOF mass spectrometer was operated in positive ionization mode and quantification was done using the MS/MS transitions at m/z 130.0 to 71.0 for metformin, 491.00 to 352.00 for glimepiride and 357.00 to 134.00 for pioglitazone. The chromatographic separation was achieved on Acquity UPLCTM BEH C18 (100.0 × 2.1 mm, 1.7μm) column using isocratic mobile phase consisting of acetonitrile-2mM ammonium acetate (50:50, v/v) at a flow rate of 0.20 mL/min. The elution of metformin, glimepiride and pioglitazone was occurred at 0.50, 1.40 and 1.22 min, respectively. The calibration curves were linear over the concentration range of 1-1000 ng/mL for all the drugs. The developed method was validated according to ICH guidelines. The method was applied for pharmacokinetic study of drugs in FDC tablets in human plasma.
Keywords
UPLC/Q-TOF-MS, Metformin, Glimepiride, Pioglitazone, FDC Tablets, Pharmacokinetic Study.- Formulation and Evaluation of Sustained Release Matrix Tablets Containing Aceclofenac and Paracetamol
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi, 110062, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 2 (2017), Pagination: 48-52Abstract
The sustained release matrix tablets were formulated and evaluated by wet granulation method. Tablets were formulated using hydrophilic polymer and binder, HPMC K100 and PVP respectively. In-vitro drug release studies were carried out in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The amount of drugs released at different time intervals were determined by validated UPLC-PDA method. In-vitro drug release from prepared tablets showed better sustained release effect when compared with marketed combination tablets. Tablets thus formulated provided extended release of aceclofenac and paracetamol over the period of 6 h.Keywords
Aceclofenac, Paracetamol, Sustained Release, Matrix Tablets, HPMC.- Formulation and In-Vitro Evaluation of a Sustained Release Matrix Tablet of Telmisatan
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi, 10062, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 9, No 1 (2017), Pagination: 19-23Abstract
The formulation and in-vitro evaluation of matrix tablets containing telmisartan as sustained release using low viscosity grade HPMC as the matrix forming hydrophilic polymer by wet granulation method. The tablets were subjected to in-vitro drug release study in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The drug released at various time intervals were determined by validated UPLC-PDA method. The prepared tablets showed better sustained release effect when compared with marketed tablets. The drug release mechanism from hydrophilic polymer was proposed. The formulated tablets provided sustained release of telmisartan over a period of 24 h.Keywords
Matrix Tablet, Telmisartan, HPMC, Hydrophilic Polymer, Sustained Release.- Formulation and In-Vitro Evaluation of FDC Bilayer Matrix Tablets Containing Telmisartan as Sustained Release and Hydrochlorothiazide as Immediate Release
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Jamia Hamdard, New Delhi, 110062, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1085-1090Abstract
The aim of the presented work was formulation and in-vitro evaluation of bilayer tablets containing telmisartan as sustained release (SR) and hydrochlorothiazide as immediate release (IR) using HPMC. Tablets were evaluated via various quality control tests and in-vitro drug release studies. Drug release study was carried out hydrochloric acid buffer of pH 1.2 (0.1N) using USP paddle apparatus. The validated HPLC-UV method was applied to determine the amount of drugs released at different time intervals. Prepared tablets showed extended sustain release of telmisartan over a period of 20 h and hydrochlorothiazide as immediate release within 30 min.Keywords
Bilayer Tablet, Telmisartan, Hydrochlorothiazide, Sustained Release, Immediate Release.- Application of Validated HPTLC Method for Dissolution Study of FDC Tablets Containing Telmisartan and Hydrochlorothiazide
Authors
1 JK College of Pharmacy, Bilaspur, CG, 495001, IN
2 Department of Pharmaceutics, Hamdard University, New Delhi, 110062, IN
3 Department of Pharmacognosy and Phytochemistry, Hamdard University, New Delhi-110062, IN